Increasing design reliability while bringing new concepts to life
Simulation of respiratory systems is a growing field in the Life Sciences Industry with applications ranging from modeling the deposition of inhaled particles into lungs to assessing the efficacy of inhaled medications.
  • Modeling the flow through nasal passages to determine the required surgical procedure using STAR-CCM+ (model provided by Lionel Meister, University of Marseille)
  • STAR-CCM+ closes the gap between meaningful results and engineering design by automating your work-flow in a unique single integrated environment. Shown here is a CFD analysis with STAR-CCM+ on a medical ventilator
  • STAR-CCM+ solution showing shear stress at wall of naval cavity during inhaling. Shear stress is high in passages with narrow cross-sections where velocity is high.
  • Polyhedral mesh for flow simulation in a human respiratory system (nasal cavity up to hypopharynx).The geometry was obtained from CT-data using software Mimics from Materialise and imported into STAR-CCM+ in STL-format (surface triangulation).
  • Polyhedral mesh for flow simulation in a human respiratory system (nasal cavity up to hypopharynx).The geometry was obtained from CT-data using software Mimics from Materialise and imported into STAR-CCM+ in STL-format (surface triangulation).

With its state-of-the-art meshing technologies, comprehensive range of physics models and easy-to-use environment, STAR-CCM+ can be used to prototype device designs before time-consuming clinical tests need to be carried out. In addition, nasal passages and respiratory tracts can be studied in silico, allowing for using patient specific data and performing virtual surgeries to aid the decision-making process. Simulations provide a means of gaining valuable insight into delicate, often inaccessible areas.

The discrete element modeling (DEM) capability in STAR-CCM+ is particularly well-suited to perform simulations of respiratory applications that involve particulate flows. The DEM capability is fully coupled with a numerical flow simulation in a single integrated software environment. It  simulates the motion of a large number of particles and tracks the interactions between them in a numerically efficient manner, modeling contact forces and energy transfer due to collision and heat transfer between the particles. DEM is ideal for many respiratory applications including studying particle deposition in human lungs and respiratory tracks (e.g. to assess effects of toxic particle inhalation or airborne pollen).

STAR-CCM+ also has a direct link to Abaqus finite element analysis through a co-simulation API developed by SIMULIA, delivering a fully coupled, implicit, two-way FSI and providing automation, efficiency and solution stability. This capability can handle FSI problems with ease including modeling of flexible lung movements.

Optimate, a module in STAR-CCM+, enables intelligent design exploration of medical devices, such as inhalers and mouth pieces, to improve on efficiency and determine critical operating parameters (e.g. flow rate). With Optimate, you can also cost-effectively perform “what if” scenarios and parametric studies to change a device design (e.g. mouth piece geometry or orientation) and pinpoint areas of recirculation with the goal of improving the efficiency of a drug delivery method.

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